About diabetes

Diabetes is a disease in which the blood glucose level is abnormally increased

There are 2 main types of diabetes:

  • Type 1 diabetes or so-called juvenile diabetes. The sugar content in the blood rises because the body’s pancreas is unable to produce the hormone insulin.
  • Type 2 diabetes, formerly called adult-onset or non-insulin-dependent diabetes. In type 2 diabetes, the body has such a large need for insulin that the body’s own production of insulin in the pancreas is unable to keep up with the body’s demand. The number of people with type 2 diabetes is rapidly increasing. The disease is associated with obesity and impaired physical activity and is therefore called a lifestyle disorder.

Other types of diabetes:

  • Gestational diabetes is similar to type 2 diabetes and occurs during pregnancy and usually disappears when pregnancy is over.
  • Secondary diabetes occurs due to another disease. This type of diabetes may occur after infection of the pancreas and in conjunction with certain medical treatments such as treatment with adrenal gland hormone.

The Symptoms:

As the blood sugar increases, the following symptoms occur:

  • thirst
  • frequent urination
  • fatigue
  • reduced appetite and weight loss
  • itching in the genital area
  • skin and mucosal infections

The symptoms are present in both type 1 and type 2 diabetes but the symptoms of type 1 diabetes develop rapidly, within a few days to weeks, while the development of type 2 diabetes is usually gradual (up to 10 years). During this period, the person can be free from symptoms.

A History of Diabetes Study

1921: Canadian doctor Frederick Banting and his 21-year-old                    medical student, Charles Best, were the first to extract insulin from a dog. In 1923, they were both honoured with the Nobel Prize.

1923: Nordic Insulin Laboratory (later Novo Nordisk) releases its first insulin preparation on the market.

1936: A new long-lasting ZPI insulin is introduced. Diabetics would now need fewer daily injections.

1959: The researchers define two types of diabetes. Type 1 diabetics who cannot produce insulin themselves and are therefore insulin dependent and type 2 diabetics who are able to produce insulin.

1974: New types of extremely pure pig-based insulin come on the market.

1986: Human insulin based on genetic engineering is introduced.

1995: Metformin tablets are offered for the first time to type 2 diabetics.

2005: A whole new category of medicine, GLP-1, is introduced to the market for treatment of type 2 diabetics as an alternative to or postponement of insulin treatment. The medicine is sold under names like Victoza, Byetta and Lyxumia.

2006: A new diabetes medication is introduced, called DPP-4(Januvia, Galvus, Tradjenta).

2013: SGLT-2 inhibitor medicine is offered for the first time to type 2 diabetics with high blood sugar levels.

About the research

Organizing diabetes research starts with the actual researchers, who can be doctors, pharmacists or biochemists. They can be employed either in the pharmaceutical industry or work in independent research institutes. The researchers experiment with gene therapy, new active substances and new technology. Once a new drug has been developed in the laboratory, tests on mice or rats begin to test the effects of the drug.

If the results of the animal testing prove successful, the next step is testing the drug on human subjects in clinical trials, which always take place where the patients are: in the hospitals and clinics. Here, the responsibility for the next step of research is passed on to the study nurses and doctors. The initial researchers are not allowed to be involved with the clinical trials to ensure they cannot affect the outcome.

Before a clinical trial can start, it must be approved by the health authorities in every country the trial takes place. The medical trial, in the form of a protocol, describes in detail the purpose of the study as well as how it is to be conducted. In addition, the Ethics Committee in all participating countries must approve the trial after carefully considering the ethical protection of the participants.

The clinical trials are conducted in four phases. It starts with phase 1, with a small number of participants and proceeds to phase 4, with several thousand participants.

It typically takes 3-4 years, from the start of a clinical trial, until new medicine is ready to be released on to the market. Not every clinical trial has the positive outcome of new medication development.